Aptamers to replace immunoassays for clinical detection of D-Dimer
Enzyme-Linked Aptamer Assay for D-Dimer Detection
Modified customized aptamer which binds to D-Dimer with high affinity
Aptamers are RNA or DNA oligonucleotides (or peptides) that, through their 3-dimensional structures, bind to specific target molecules with high affinity and specificity.
Aptamers are generated fast and applied in the inhibition, characterization of proteins, and specific detection.
D-Dimer Tests are Used to Help Rule Out Suspected:
Pulmonary Embolism (PE)
Deep Venous Thrombosis (DVT)
Disseminated Intravascular Coagulation (DIC)
The Aptamer Pair-Based Sandwich-Type BioSensors
Knowing the exact target sites of the D-Dimer protein, scientists at Ayass BioScience, LLC are making a wide variety of chemical modifications to the aptamers in order to target their functions. The process of developing these aptamers are uniform due to the highly controlled environment in-vitro. Aptamers are resistant to temperature insults by returning to original confirmation after the insult, have unlimited shelf-life and are not immunogenic. All of these characteristics make these aptamers ideally suited to overtake immunoassays in the clinical D-Dimer diagnostics.