Development of Therapeutic Neutralizing DNA Aptamers Against SARS-CoV-2
Aptamers are RNA or DNA oligonucleotides (or peptides) that, through their 3-dimensional structures, bind to specific target molecules with high affinity and specificity. Aptamers are generated fast and applied in the inhibition, characterization of proteins, and specific detection.
Our Aptamers are S-Protein Specific and may be a Specific Therapeutic Agent for COVID-19 therapy.
Our Aptamers not only neutralize the SAR-CoV-2 Wild Type strain, but also neutralize alternate strains of SAR-COV-2: Delta, Mu, Delta+, Omicron, etc.
Our Aptamers specifically block the uptake of Pseudo-SAR-CoV-2 VLP by lung cells in vivo mouse model.